Body hacks 4.

There has been a week’s delay for this, as we were on holiday. This meant that we have to modify what we do. Firstly, we found that the standard Kiwi cooked breakfast, even if you ask for no bread and for a salad (and we did) was loaded with carbohydrates. There was not enough nutrition to get us lasting the whole day. We found that when fat adapted, carbohydrates lead to inflammation and fluid retention. We found that many people hide spices — and this is NZ, where we don’t have GMO foods and most animals are grass fed.

We did not lose weight. We gained.

But this week, we managed to do OMAD fairly well, and we lost not only what we gained but have both had gains. Despite this being the week of the month with the most travel.

I credit animal fat for this. If you are doing OMAD, you have to eat fat. If you don’t you will fall over. If you do, you will still be in calorie deficit. GIven that we have people who have inflammatory reactions to almost everything (Kea reacts to milk, grains and nightshades, Weka can’t tolerate sugars and starches) getting enough nutriends in is a challenge.

And animal fat may not be bad for you.

Absent a time machine, it’s impossible to know how publication of the study, conducted in Minnesota from 1968 to 1973, might have influenced dietary advice. But in an accompanying editorial, Lennert Veerman of Australia’s University of Queensland concluded that “the benefits of choosing polyunsaturated fat over saturated fat seem a little less certain than we thought.”

The Nixon-era experiment had produced only a single journal paper, in 1989, which concluded that replacing saturated fats found in meat and dairy products with vegetable oils did not reduce the risk of coronary heart disease or death. But it had few quantitative data and little statistical analysis, and was silent on many of the questions the researchers told NIH, which funded it, they intended to answer.

Ramsden wondered if there was more data from the study somewhere.

In 2011, he sought out the sons of the experiment’s principal scientist, Dr. Ivan Frantz of the University of Minnesota, who died in 2009.

“I told him I recalled lots and lots of records, whole chests full of records—IBM [computer] tapes—back in Minnesota,” said Dr. Ivan Frantz III, a neonatologist at Beth Israel Deaconess Medical Center in Boston.

Dr. Robert Frantz, a physician at the Mayo Clinic, drove 90 minutes to his childhood home, to search file cabinets. On his third trip he spied moldering, unlabeled boxes in the far corner of the basement. Inside were ancient magnetic computer tapes and reams of yellowed documents. The subject line in his email to Ramsden was “Eureka.”

After getting the tapes translated into formats that modern computers can read, Ramsden and his colleagues discovered what had been hidden for nearly half a century: records on 9,423 study participants, ages 20 to 97, all living in state mental hospitals or a nursing home. It was the largest experiment of its kind.

Risk of death from any cause by diet assignment in full MCE cohort and prespecified subgroups (Kaplan Meier life table graphs of cumulative mortality). Graphical depiction of cumulative mortality in full MCE cohort (n=9423) and prespecified subgroups in 1981 Broste thesis7 showed no indication of benefit and suggested possibility of unfavorable effects of serum cholesterol lowering intervention among participants aged ≥65. Patient level data needed to repeat this analysis were not recovered

The basic science between the dietary hypothesis — replacing animal fat with vegetable fat — is probably flawed. By the way, grow your own if all possible. The older, heritage vegetables and fruits will be more nutritious.

We eat our meal at either breakfast or lunch. When we do this (and do not eat extras) I note that by blood glucose drops 2 mmol/l. Via Mark Sisson (you should look at his weekly linkage, there appears to be benefit in eating early.

24-Hour Glucose Levels. Relative to the control schedule, early time-restricted feeding (eTRF) (A) changed the temporal profile of 24-hour glucose levels, as measured by continuous glucose monitoring, particularly in the evening, (B) lowered mean glucose levels while asleep and decreased 24-hour mean glucose levels, and (C) lowered glycemic excursions as measured by Mean Amplitude of Glycemic Excursions (MAGE). Error bars on panel (A) are suppressed for visual clarity. * p < 0.05.
Weka Kea
Weight change this week 1.5 kg 2.9 kg
Total weight change.

(five weeks)

6 kg 6.4 kg